Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors
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چکیده
منابع مشابه
Regeneration of Hippocampal Pyramidal Neurons after Ischemic Brain Injury by Recruitment of Endogenous Neural Progenitors
The adult brain is extremely vulnerable to various insults. The recent discovery of neural progenitors in adult mammals, however, raises the possibility of repairing damaged tissue by recruiting their latent regenerative potential. Here we show that activation of endogenous progenitors leads to massive regeneration of hippocampal pyramidal neurons after ischemic brain injury. Endogenous progeni...
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Glutamate induces excitotoxic damage to hippocampal pyramidal neurons in Status Epilepticus (SE) and epilepsy. In this study, we investigated time course of dysregulation of calcium homeostasis at various intervals after an episode of SE in acutely isolated CA1hippocampal pyramidal. For this purpose, male Sprague-Dawley rats (200 g) were subjected to pilocarpine-induced SE. The SE was blocked a...
متن کاملTime course of dysregulation of calcium homeostasis in acutely isolated CA1 hippocampal pyramidal neurons after pilocarpine-induced Status Epilepticus
Glutamate induces excitotoxic damage to hippocampal pyramidal neurons in Status Epilepticus (SE) and epilepsy. In this study, we investigated time course of dysregulation of calcium homeostasis at various intervals after an episode of SE in acutely isolated CA1hippocampal pyramidal. For this purpose, male Sprague-Dawley rats (200 g) were subjected to pilocarpine-induced SE. The SE was blocked a...
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Strokes are a major cause of death and result in a drastic reduction in the quality of life. The only effective therapeutic approach is thrombolysis with recombinant tissue plasminogen activator, and a new strategy to minimize ischemic-related damage is thus required. Over the past 10 years, regenerative therapy, which supplies new neurons or oligodendrocytes, has been extensively studied. Two ...
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ژورنال
عنوان ژورنال: Cell
سال: 2002
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(02)00862-0